The assessment of histone acetylation marks in the vicinity of transcription factor binding sites in human CD4+ T cells using information theory methods

Abstract

The genetic information encoded in structural genes is decoded by an intracellular process called gene expression. This mechanism is regulated by epigenetic processes such as histone acetylation. Histone acetylation, which happens in nucleosomes, exposes DNA (genome) to transcription factors. Therefore, the correlation between histone acetylation and gene expression has been assessed as a fundamental issue in many previous studies. In the proposed research, we investigate which marks of histone acetylation are informative and which ones are redundant in the vicinity of SP1 transcription factor binding sites, in human CD4 + T cell. To achieve this, we use information theory methods. Subsequently, we apply a multilayer perceptron neural network to show that the selected histone acetylation marks by information theory methods are sufficiently informative. Finally, we use the neural network to predict …

Fatemeh Zare

Associate Professor

My research interests include bioinformatics, computational biology and artificial intelligence.