Genome-scale metabolic models are increasingly becoming available for a variety of microorganisms.This has spurred the development of a wide array of computational tools, and in particular, mathematical optimization approaches, to assist in fundamental metabolic network analyses.
In this presentation, first, basic definitions and concepts of metabolic networks demonstrated. Then, BiGG database for using genome-scale metabolic networks introduced. After that, modeling and formulating metabolic networks via stoichiometric matrix explained. Then, the problem of metabolite protein interaction expressed and experimental and computational methods represented and STITCH database demonstrated.