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RNA-targeting small molecule drugs

Generally, drug targets are proteins. But only 15 percent of proteins have a proper active site. So researchers thought of RNA as an alternative solution. We know RNA molecules play an important role at all stages of cell life by delivering cellular information and gene regulation due to its structure and its relationship with biological function. As a result RNA become a potential therapeutic target. With new sequencing technology researchers are able to use small molecules that can bind to RNA secondary or tertiary structures to change their translation patterns, localization, and degradation.

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